CST - Akt, antibody, cell Signaling Technology
Hyperactivity of the pathway promotes the epithelial-mesenchymal transition (EMT) and metastasis due to its effects on cell migration. Activated Akt causes FoxO degradation, so it can no longer inhibit PP2A, thus leading to a decrease in Akt phosphorylation. 23 The pathway is also controlled by protein phosphatase 2A (PP2A which dephosphorylates Akt at Thr308 and phosphatase phlpp dephosphorylates Akt at Ser473.
Cell Signaling Technology, pathways
This stimulates vasodilation and vascular remodelling. 27 Akt has also been shown to phosphorylate murine double minute 2 (Mdm2 a key regulator of DNA damage responses, at Ser166 and Ser186.
Akt/PKB signaling pathway, wikipedia
"Akt2 regulates expression of the actin-bundling protein palladin". 1 Mutation in the pathway can also affect receptor tyrosine kinases, growth factors, Ras and the PI3K p110 subunit, leading to abnormal signalling activity.
CST - Product Pathways: PI3K akt
Castellano E, Downward J (2011). A b c d e f Vanhaesebroeck B, Alessi DR (2000). "The Phosphoinositide 3-Kinase Pathway". 45 HIF promotes gene expression of vegf and glycolytic enzymes, allowing metabolism in oxygen-depleted environments. J Natl Cancer Inst.
Siga - Sistema Informaci n General aktmotos
Meima ME, Webb BA, Witkowska HE, Barber DL (2009). 21 Regulation edit Examples of feedback control in the PI3K-Akt Pathway The PI3K-Akt pathway has many downstream effects and must be carefully regulated.
CST - PI3K akt (PI3K akt)
Initial stimulation by one of the growth factors causes activation of a cell surface receptor and phosphorylation of PI3K. Aberrant activation of Akt, either via PI3K or independently of PI3K, is often associated with malignancy. 2 12 Akt also phosphorylates MAP kinase kinase kinases (mapkkk) upstream of the stress-activated protein kinase (sapk) pathway. 2, the pathway is highly regulated by multiple mechanisms, often involving cross-talk with other signalling pathways. Therefore, many of the proteins in the pathway are targets for cancer therapeutics.
Stock" (U.S.: Nasdaq) - MarketWatch
Akt target substrates contain a minimum consensus sequence R-X-R-X-X-Ser/Thr-Hyd, where Hyd is a hydrophobic amino acid, although other factors such as sub-cellular localisation and 3-dimensional structure are important. Liu P, Cheng H, Roberts TM, Zhao JJ (2009). Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Pandolfi PP, Jiang X (2007). "AKT/PKB Signaling: Navigating Downstream". Manning BD, Cantley LC (2007 aKT/PKB signaling: navigating downstream.